I'll admit I haven't read every line of the past couple of FML's so if this has been mentioned as part of the debate I apologize. Other than ensuring several weeks apart I didn't used to agonize about vaccinating. Then I started learning more (the anthrax vaccine thing has been a huge eye opener) so I am no longer in the all vaccinations all the time camp now. However - distemper is not negotiable. Its too contagious, its everywhere all the time and its deadly. But how bout this - after the initial series and booster - do a titer test. I know the problem is that when you do the titer test things may be fine and the ferret protected - but you won't know when that changes exactly. But for ferrets who have had reactions it may help limit the number/frequency of distemper shots and still provide more protection than no shots at all. ?? Mary "For that which befalleth the sons of men befalleth beasts; even one thing befalleth them: as the one dieth, so dieth the other; yea they have all one breath; so that a man hath no preeminence above a beast: for all is vanity. " Ecclesiastes 3:19 [Posted in FML issue 3241]