Okay, I've missed a few FML's lately but have read the recent concern over the distemper vaccine. Count us in the category of folks who have almost lost a ferret to an immediately life-threatening anaphylactic (sp?) reaction to the distemper vaccination. However, in our case IT WAS GALAXY-D that caused the reaction, *not* Fervac. Luckily, Xena survived and seems to be fine now. This was two years ago and we have not vaccinated her since. Then there are inflammatory nodules and fibrosarcoma, both caused by the rabies vaccine, if I understand correctly. There is an adjuvant in the vaccine that is supposed to provide the necessary inflammatory reaction to get the immune system started so it will react to the killed rabies virus and produce antibodies. One of our cats recently developed fibrosarcoma at the injection site. Luckily, the injection site was the hind leg (changed specifically because of such concerns) and we think the vet got it all. One of our other ferrets, Bear, also developed a *huge* lump on his back that we were afraid was fibrosarcoma but came back as simply an inflammatory lump, caused also by the vaccine. This was last year. *This* year, yet another of our babies, Gabrielle, had a reaction, this time to her *rabies* vaccination! Again luckily, it did not seem to be immediately life-threatening. She vomited and was very lethargic, but she never lost consciousness and was fine after a few hours and an injection of dextramathoraphan. My main question is this -- are we going to have to keep dealing with these things? Specifically, should Gabby be vaccinated again next year? I've heard that reactions have a tendency to get worse every time. WHAT DO WE DO? I'm at the point where I don't want to vaccinate anyone for anything! :(:( -Tasha [Posted in FML issue 3239]