Dear Katharine: Dr. Wiliams posted: >>A better preventative would be Benadryl - as histamine is released >>during anaphylaxis, and mediates most of the reaction including airway >>constriction and blood vessel leakage, an antihistamine like Benadryl >>(2 mg 10 minutes prior) is at least a logical step. >2mg per what? kg? pound? Actually, per ferret - Usually averages about 2mg/kg. Benadryl has a very high margin of safety so I prefer to err on the high side than on the low side. And the 10 minutes applies to IM injection. (Remember, I say that it works anecdotally - there are no real studies that have proven the utility of the antihistamine, but it certainly doesn't hurt. ) I would suggest 30 minutes prior at least if given orally. Now I can't give you a dose for your particular bottle unless you can give me a concentration. Who makes it - perhaps we can find it in the PDR.... With kindest regards, Bruce Williams, DVM [Posted in FML issue 3201]