There are several - - Lupron (both depot and 24 hour) - can be expensive - Lysodren - relatively inexpensive - Melatonin - inexpensive - Casodex - very expensive - Riley Adrenal Recipe - initially a bit expensive but well worth it I've used the 24 hour lupron (given every 2-4 weeks) to help keep at bay prostate problems in the boys with good results. Ferris is going in for his Lupron depot (time-released) injection tomorrow. His surgery was unsuccessful - both adrenals looked normal with only the left having a darkened spot so Larry removed it - and I've had him on and off Baytril and 24 hour lupron for a couple months so we are going to try the lupron depot for him. I really didn't want a second surgery to remove the right as we've not had good results on very many of the bi-laterals. I'm hoping the Lupron depot will give us a good 6 months of no adrenal symptoms (and me a break). I've used Lysodren with mixed results. It also can lower blood sugar but that can be controlled with a wee bit of pediapred in those cases. When it works, it works. I've not tried Melatonin but have been considering it. I'm sure I'll have the opportunity sometime in the near future. I've got two that are possibly early adrenal and they are certainly in the running for it. We used Casodex on one boy but it didn't work for him and the cost was prohibitive. I've not used the Riley adrenal recipe but have heard good results from others who have used it. Information on adrenal disease and treatments can be found on Mike's page - http://www.miamiferret.org/fhc/ Hugs. tle Troy Lynn Eckart Ferret Family Services http://www-personal.ksu.edu/~sprite/ffs.html http://www.geocities.com/Petsburgh/Haven/5481/ Please sign up to support our charity http://www.iGive.com/html/ssi.cfm?cid=46&mid=58395 [Posted in FML issue 3146]