It sounds like she is going into a false estrus from the adrenal
disease.  If you do not correct this she seems more likely, given the
swollen vulva also being present to go into aplastic anemia, which is
a nasty and needless way to die when treatments could be effective.
 
She NEEDS treatment: surgery, Suprelorin Depot, or Lupron Depot and
melatonin implant.
 
Sadly, doing well short term and being a bit hyper from the increase
in hormonal output does not equate to good good term results.
 
It is also perhaps possible that adrenal related vulvar swelling has
caused enough irritation to cause an epocrine cyst or tumor, though
that is much, much less likely.
 
Quoting Dr. Bruce Williams to help get across why it is so important
to provide treatment for these ferrets:
 
http://fhl.sonic-weasel.org/browse.php?msg=SG5054
 
>I think that Melissa and Sukie have covered the dire possibilities
>very well (and they are very real.)
>
>However, even under the best conditions, when there is no malignancy,
>there is no bone marrow toxicosis, there is no prostatic cystic
>disease - even the most mild prediction is a sad one.  Ferrets with
>adrenal disease have a diminished quality of life - they have
>progressive muscle loss, low grade anemia, they tend to redistribute
>weight to the abdomen, further making it difficult to walk, they have
>an increased incidence of gastric ulcers as a result of the stress of
>chronic illness, decreased bone density - none life-threatening, but
>all life-compromising.  Even medical treatment, which is not my
>preferred way of treating adrenal disease, gives slight releif to
>symptoms.  Doing nothing is not kind and not in a ferret's best
>interest.
 
-- Sukie (not a vet, and not speaking for any of the below in my
private posts)
Recommended health resources to help ferrets and the people who love
them:
Ferret Health List
http://www.smartgroups.com/groups/ferrethealth
FHL Archives
http://ferrethealth.org/archive/
AFIP Ferret Pathology
http://www.afip.org/ferrets/index.html
Miamiferrets
http://www.miamiferret.org/fhc/
International Ferret Congress Critical References
http://www.ferretcongress.org
[Posted in FML issue 5341]