I looked this up on the internet and I can understand why it was taken
off the US Market.  If you want to order it, the only way is thru the
Canadian Pharmacy on the internet.  I don't have that site.  BIG, if
this is to be big to in on the FML let me know.
 
Thank You
Marie and her 5 Most Wonderful Fur Kidlets (Ferret Nanny on the 22 Aug, 3
more coming in, until June 30th 2005)
 
[Moderator's note: Looks like it just squeezed through the size limit.
Material from nih.gov can be reproduced here, so that's fine too.  BIG]
 
http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202577.html
 
Description
 
Trilostane ( TRYE-loe-stane) is used in the treatment of Cushing's
syndrome.  It is normally used in short-term treatment until permanent
therapy is possible.  In Cushing's syndrome, the adrenal gland
overproduces steroids.  Although steroids are important for various
functions of the body, too much can cause problems.  Trilostane reduces
the amount of steroids produced by the adrenal gland.  This product was
withdrawn from the U.S.  market in April 1994.Other medical problems The
presence of other medical problems may affect the use of trilostane.
Make sure you tell your doctor if you have any other medical problems,
especially:
 
Infection or
Injury (recent serious) Trilostane may weaken the body's normal defenses
 
Kidney disease
 
Liver disease Precautions While Using This Medicine
 
It is very important that your doctor check your progress at regular
visits to make sure that trilostane is working properly and does not
cause unwanted effects.  Check with your doctor right away if you get an
injury, infection, or illness of any kind.  This medicine may weaken your
body's normal defenses.  Before having any kind of surgery (including
dental surgery) or emergency treatment, tell the medical doctor or
dentist in charge that you are taking trilostane.  Your doctor may want
you to carry a medical identification card or wear a bracelet stating
that you are taking this medicine.  Side Effects of This Medicine
 
Along with its needed effects, a medicine may cause some unwanted
effects.  Although not all of these side effects may occur, if they do
occur they may need medical attention.  Check with your doctor as soon
as possible if any of the following side effects occur:
 
Rare
 
Darkening of skin; drowsiness or tiredness ; loss of appetite; mental
depression; skin rash; vomiting
 
Other side effects may occur that usually do not need medical attention.
These side effects may go away during treatment as your body adjusts to
the medicine.  However, check with your health care professional if any
of the following side effects continue or are bothersome:
 
More common
 
Diarrhea;  stomach pain or cramps
 
Less common
 
Aching muscles; belching or bloating ; burning mouth or nose; dizziness
or lightheadedness; fever; flushing; headache; increase in salivation;
nausea; watery eyes
 
Other side effects not listed above may also occur in some patients.  If
you notice any other effects, check with your doctor.
 
Revised: 10/16/2000
Micromedex, Inc. Disclaimer
http://www.axiomvetlab.com/EF%202-1.html
 
 
Trilostane Treatment in Canine Cushing's Syndrome
 
Summary
Spontaneous hyperadrenocorticism (Cushing's) is a common clinical
syndrome in dogs, resulting from excessive circulating cortisol
concentrations.  This is usually caused by an ACTH secreting pituitary
tumour (85% of cases) but occasionally results from an adrenal gland
tumour.  Recently "Vetoryl" (active drug: trilostane) has been licensed
for treatment of canine Cushing's disease.  Trilostane blocks the normal
adrenal steroidogenesis pathways, causing a reduction in circulating
hormone concentrations in many affected cases.
 
Unlike mitotane, Trilostane is given daily for life.  Initial starting
dose varies but a common daily starting dose is approximately 60 mg
(dogs between 5-20kg), 120mg (dogs between 20-40kg) and 120-240mg (dogs
>40kg).  Monitoring should consist of:
Clinical evaluation within 2-4 weeks
ACTH stimulation testing: perform 4 hours after giving that day's
Vetoryl medication
 
Vetoryl Monitoring Protocol
Collect fasted whole blood sample four hours after giving Vetoryl
Administer 250mg ACTH (Synacthen) intramuscularly Collect second whole
blood sample one hour later  Label tubes "pre" and "post" accordingly
Submit to Axiom and indicate that dog is receiving Trilostane
therapy  Results and full interpretation will be available on the day
of receipt (Mon-Fri)  If required, endocrine staff will be available to
discuss the case further at no extra charge
 
Further Information
For further information on canine hyperadrenocorticism or Trilostane
therapy in particular please feel free to call Axiom where one of the
veterinary clinical pathologists will be happy to help.  Alternatively
the following references may be of interest:
 
Neiger, R.  and Hurley, K.  (2000) Long term efficacy and safety of
trilostane for treatment of canine hyperadrenocorticism, Journal of
Veterinary Internal Medicine, 124, 376 Neiger, R. and Hurley, K. (2001)
24 Hour cortisol values in dogs with hyperadrenocorticism on trilostane.
Proceedings of the BSAVA congress, Birmingham, p549. Hurley, K.J. (1998)
Trilostane in the treatment of canine hyperadrenocorticism.  ESVIM
congress, Vienna
[Posted in FML issue 4607]