>From:    Fred A Hurd <[log in to unmask]>
>Subject: Need Lupron info
>Okay here is the situation.  I took my old sable named Smokey to the vet
>today and I asked about Lupron.  My Vet is Dr, Patty McCormick and Dr.
>Patty hadn't heard of it by that name.  She asked what family of drugs was
>in from and I told her I didn't know but I wondered if it wasn't like
>Interferon (SP?) ...
 
Fred, your vets may be able to find out more about Lupron if they looked
for Leuprolide Acetate.
 
Here is a little on the pharmacology of Lupron, extracted from an article
on Lupron vs. Lysodren usage for adrenal disease treatment by Jerry
Murray, DVM.  You can read the entire article on my Adrenal/Insulinoma
website (see my signature below for the site URL) or go directly to the
page using this link... http://www.miamiferret.org/fhc/murray.htm
 
"LUPRON DEPOT is a synthetic analog of GnRH.  It acts as a potent inhibitor
of GnRH secretion.  This results in decreased levels of LH and FSH.  This
results in decreased levels of the sex steroids and the androgens.  These
decreases occur within 2-4 weeks and have been demonstrated to last for
more than 5 years with continuous use in people.  Many animal studies were
done by TAP Pharmaceuticals in rats, mice, dogs, monkeys, and rabbits.  In
humans it is used to treat endometriosis, uterine fibroids, mammary tumors,
and prostatic tumors.  In ferrets Lupron works by the same mode of action.
It stops GnRH secretion by the hypothalamus, which stops LH and FSH
secretion by the pituitary, which stops the stimulation to the adrenal
glands, which stops the production of the sex steroids and adrogens by the
adrenal glands (zona reticularis).  The improvement in clinical signs is
usually rapid and impressive."
 
For the ferrets,
Mike
 
* Michael F. Janke, [log in to unmask]
* South Florida Ferret Help Line, 305-752-7040
*
* Website:  http://www.miamiferret.org
* Adrenal/Insulinoma web site: http://www.miamiferret.org/fhc
[Posted in FML issue 3079]