This class of drugs MUST be given in a slow release form, so for
Lupron that is the DEPOT while for Deslorelin it is the IMPLANT
known as Suprelorin.

The daily forms can actually WORSEN adrenal disease. See
http://www.miamiferret.org/24hr_lupron.htm

Including
"... if the Lupron is of the type that all enters the bloodstream in
24 hrs., (24 hr. Lupron) what you get is a few hours of high pituitary
activity followed by only several HOURS of inactivity (desensitized).
Then the 24 hr. Lupron is gone shortly thereafter, and the pituitary
RE-sensitizes and LH release to the natural GnRH resumes probably in a
day or so. If the ferret is only getting the 24hr. shot once a month,
it's useless. In fact, the use of the 24 hr. Lupron probably makes the
adrenal disease worse because you don't get much therapeutic effect,
but you are still getting that initial high pituitary activity when the
Lupron is first administered. This initial burst of pituitary activity
is of little consequence when it is followed by cessation of pituitary
activity. But, with the 24 hr. Lupron, you get only the initial burst
of pituitary high activity -- followed by normal pituitary activity.
It's like adding a splash of gasoline to a fire."

Both Mike and I heard from people who tried the 24 hour Lupron only to
have their ferrets suddenly worsen, so be sure what you are getting,
please.

[Posted in FML 8062]