As Mike pointed out, the first thing to do is find out the actual dose of
Lupron that is being used.  The dose range is 100-500 mcg/kg, so she may
just need a higher dose to get the hormones under control.  She may be in
the 10% or less group that does not respond to Lupron.  (Most of these
are carcinomas or right glands that have spread to the liver.) The other
medication that can be used with Lupron is melatonin (1mg once a day
about 8-9 hours after sunrise).
 
If the Tenn panel was done to confirm adrenal disease then we know which
hormone(s) was elevated.  Then possibly Arimidex (to lower estrogen
levels) or Propecia (to lower DHT levels) may help.  Another thing to
consider is the aggressive behavior may be a behavioral problem, so
Prozac may help solve that problem.
 
For itchy skin frequent baths with Relieve shampoo and Resicort
conditioner, and a fish oil supplement (EFA caps liquid) sometimes helps.
 
Thus there is alot of options to try before you give up on this one.  Of
course if all else fails then surgery is the other option to consider.
 
Hope that helps,
Jerry Murray, DVM
 
[Quick Sukie Note:  Notice that surgery is the usual preferred
approach, but sometimes -- as now -- an individual may be a poor
surgical candidate due to other health problems.]
[Posted in FML issue 4317]