Dear Russ - A splenic aspirate may give us some valuable information - at
least let us know what is going on.  Extramedullary hematopoiesis, the
cause of splenomegaly in about 95% of cases, is commonly the result of
chronic GI inflammation (coronavirus also causes a large number of cases.)
 
The problem with empirically treating the spleen is that they seem to have
memory - even if you knock it down, the next time there is any inflammation
at all systemically - BOING - it's back to its enlarged size (and maybe
more) again.
 
I generally only recommend treating Helicobacter to diminish GI signs -
not splenic enlargement.
 
If you want to go after the spleen, then remove it.  I have never seen an
animal suffer systemic illness as a result of splenectomy.  However, I
have seen them rupture big spleens.
 
With kindest regards,
Bruce Williams
[Posted in FML issue 3457]