FERRET-SEARCH@LISTSERV.FERRETMAILINGLIST.ORG
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Date: | Wed, 22 Jan 2014 16:20:23 -0500 |
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http://www.ncbi.nlm.nih.gov/pubmed/24437088
Yes, this IS ferret related. Look for the work of Bob Wagner and Mark
Finkler referenced in the final comment
J Zoo Wildl Med. 2013 Dec;44(4 Suppl):S84-96.
Twenty years of immunocontraceptive research: lessons learned.
Miller LA, Fagerstone KA, Eckery DC.
Author information
Abstract
The National Wildlife Research Center (NWRC) began immunocontraception
vaccine research by testing porcine zona pellucida (PZP) on
white-tailed deer (Odocoileus virginianus). Early PZP research
demonstrated that PZP induced infertility; however, increased length of
the rut was observed in PZP-treated deer. An alternative vaccine using
a keyhole limpet hemocyanin-gonadotropin-releasing hormone (KLH-GnRH)
conjugate formulated with modified Freund's adjuvant was developed at
NWRC. Suppression of GnRH has reduced reproduction in both sexes but
is most effective in females. This vaccine was effective in preventing
contraception in female deer for several years after a prime and boost.
Due to adverse side effects of Freund's adjuvant, NWRC developed a new
adjuvant called AdjuVac, a mineral oil/surfactant adjuvant with the
addition of Mycobacterium avium as an immunostimulant. The price of KLH
prompted a search for a more economical hemocyanin carrier protein for
the GnRH peptide. Blue protein, derived from the mollusk Concholepas
concholepas, proved to be a successful option. Formulation improvements
resulted in a vaccine that can be effective as a single injection for
multiple years, now called GonaCon. GonaCon is registered with the
Environmental Protection Agency (EPA) for use in white-tailed deer in
urban/suburban areas and for wild horses (Equus caballus) and burros
(Equus asinus). Future GonaCon applications may include reducing
reproduction to manage populations of other wildlife species, such as
prairie dogs (Cynomys ludovicianus) in urban areas and suppressing
reproduction to reduce the spread of venereal diseases such as
brucellosis. Research is being conducted to develop a GnRH vaccine used
in combination with the rabies vaccine to control population growth in
free-roaming dogs, with the secondary effect of managing the spread of
rabies. The EPA would regulate all these uses. Research is also ongoing
on a GnRH vaccine to delay the onset of adrenocortical disease in pet
ferrets (Mustela putorius), a use regulated by the United States
Department of Agriculture.
PMID: 24437088 [PubMed - in
[Posted in FML 8024]
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