http://www.ncbi.nlm.nih.gov/pubmed/24018315

There is info in past posts on what temp food needs to be cooked to to
kill this disease.

Do not confuse this with other forms of hep.

QUOTE

J Gen Virol. 2013 Sep 9. [Epub ahead of print]
Characterization of self-assembled virus-like particles of ferret
hepatitis E virus generated by recombinant baculoviruses.

Yang T, Kataoka M, Ami Y, Suzaki Y, Kishida N, Shirakura M, Imai M,
Asanuma H, Takeda N, Wakita T, Li T.

Source
Department of Clinical Laboratory, Affiliated Hospital of Qingdao
University;

Abstract
Ferret hepatitis E virus (HEV), a novel hepatitis E-like virus, has
been identified in ferrets in the Netherlands. Due to the lack of a
cell culture system for ferret HEV, the antigenicity, pathogenicity and
epidemiology of this virus have remained unclear. In the present study,
we used a recombinant baculovirus expression system to express the
112-N-terminus and 47-C-terminus amino-acid-truncated ferret HEV ORF2
protein in insect Tn5 cells, and found that a large amount of a 53 kDa
protein (F-p53) was expressed and efficiently released into the
supernatant. Electron microscopic analysis revealed that F-p53 was
self-assembled into virus-like particles (ferret HEV-LPs). These ferret
HEV-LPs were estimated to be 24 nm in diameter, which is similar to the
size of G1, G3, G4 and rat HEV-LPs derived from both the N-terminus-
and C-terminus-truncated constructs. Antigenic analysis demonstrated
that ferret HEV-LPs were cross-reactive with G1, G3, G4 and rat HEVs,
and rat HEV and ferret HEV showed a stronger cross reactivity to each
other than either did to human HEV genotypes. However, the antibody
against ferret HEV-LPs does not neutralize G3 HEV, suggesting that
the serotypes of these two HEVs are different. An enzyme-linked
immunosorbent assay (ELISA) for detection of anti-ferret HEV IgG and
IgM antibodies was established using ferret HEV-LPs as antigen, and
this assay system will be useful for monitoring ferretHEV infection in
ferrets as well as other animals. In addition, analysis of ferret HEV
RNA detected in ferret sera collected from a breeding colony in the
USA revealed the genetic diversity of ferret HEV.

KEYWORDS:
ELISA, Ferret HEV, Recombinant baculovirus, Virus-like particles

PMID: 24018315 [PubMed - as supplied by publisher]

[END QUOTE, I assume]

[Posted in FML 7903]