If the ferret's liver is at all compromised the Prednisolone will be
more effective than the Prednisone, so your vet may adjust the dose
downward depending blood glucose results if this is being used for
insulinoma.

On the other hand, if it is being used for lymphoma or an autoimmune
disorder the vet will only adjust the dose in relation to the
concentration change. Bravo to you for noticing the concentration! It
is an absolutely essential aspect to notice with medications but too
many people do not do so. The higher the concentration, the more med
there is in the same volume. For those here who have not paid attention
to that: failure to do so can have the ferret getting the wrong dose
so with liquid meds always check the mg/ml numbers on the bottle.

The liver has to convert Prednisone to Prednisolone for the body to
utilize it. The result is that a compromised liver can not convert
much. For ferrets with very compromised livers Prednisone may as well
be water but Prednisolone will still work. We had one who was markedly
like that who needed the med for an autoimmune problem with the change
to Prednisolone being such a win for him and totally turning his health
around, and we have had a few over the decades who were somewhat like
that.

Sukie (not a vet) Ferrets make the world a game.

Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html

"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)

A nation is as free as the least within it.

[Posted in FML 7812]