These are in the same class of drugs as Lupron depot but longer acting. They can be given with melatonin implants (which is what I suspect you meant to ask but had a typo) and as Dr. Jerry Murray has pointed out in the FHL this class of drug and melatonin help in different and complimentary ways. You would not give Lupron and deslorelin together, though, because they are related drugs. Deslorelin is the generic of what is used in the unique Suprelorlin implant technology. More info besides that in the FHL's very easily searched archives: http://www.peptech.com/HTML/Animal_Health/Superlorin_general.html The FHL Archives are open for anyone to use, and the FHL itself can be read by non-members at the website, though posting requires membership. The aim is that way to help the maximum number of ferrets and people since not all want to join but could still be aided by the information available. Sukie (not a vet) Recommended ferret health links: http://pets.groups.yahoo.com/group/ferrethealth/ http://ferrethealth.org/archive/ http://www.afip.org/ferrets/index.html http://www.miamiferret.org/ http://www.ferrethealth.msu.edu/ http://www.ferretcongress.org/ http://www.trifl.org/index.shtml http://homepage.mac.com/sukie/sukiesferretlinks.html all ferret topics: http://listserv.ferretmailinglist.org/archives/ferret-search.html [Posted in FML 6530]