Lupron is one of the drugs which is used in treating existing adrenal
disease.  Often it will be used in conjunction with melatonin.  When
there are certain complications other meds amy also be needed such as
Proscar/Propecia for prostate enlargement which seems to be by far the
most common life-threatening complication.  FML members can see by
reading up on adrenal disease that there are many reasons why surgery is
usually the best bet for adrenal disease.
 
Prednisolone/Prednisone is not useful for treating adrenal disease, but
you will find it used for one problem related to adrenal disease which
can happen.
 
Prednisolone/Prednisone is used to treat Addison's which develops if the
adrenals are completely removed.  (Note the word "completely" because
many vets wind up leaving a bit behind.) or if the adrenals cease
functioning (Sometimes when one is diseased the other will be suppressed
temporarily or less often may atrophy, and Lysodren which has been mostly
abandoned for treatment of adrenal disease also sometimes causes adrenal
atrophy and can thus be suddenly fatal, whereas other times Lysdoren just
doesn't work at all.)
 
Prednisolone/Prednsione is typically used in conjunction with either
Percorten or Florinef/Fludrocort when it is needed for this use.
 
When that mix of drugs is needed it is absolutely essential fort
survival.  You see, some adrenal products help the body maintain the
correct amounts and proportions of electrolytes which are needed for
cell function and survival, and some also are needed for the body to
maintain proper hydration.  You can see why lacking them is fatal.
 
Now, on very, very, very rare occasions people have had ferrets who have
had surgery on both adrenal of a ferret and the ferret continues to need
the drugs which help avoid Addisons Crises, but they have never-the-less
begun to overproduce hormones as with normal adrenal disease.  In those
ferrets it is thought that the sections which were left behind are able
top produce hormones but not the steroidal products of the adrenal, hence
the need for meds to tackle both in those rare individuals.
 
So, to sum up: you are asking about drugs which are needed for two
DIFFERENT things.  Neither can be used to replace the other.
[Posted in FML issue 4673]