No one knows how long over a year the vaccines used for ferrets last.
All that is know is that they do last at least a year.
 
How long they last in other species doesn't matter, BTW.  An example of
why can be found in the studies when existing rabies vaccines were tested
in ferrets, of those that worked (one well which is the Imrab 3 we use
today, one with a huge amount of bad side effects and those ferrets were
adopted by the testing vet and her workers so went on to be loved through
their lives) was a vaccine that normally lasts a decent time in other
animals.  In ferrets it provided only 6 months of protection despite
providing long protection for other species.
 
I do recall a situation around here where someone was talked into trying
an alternative med non-vaccine "vaccine".  She went about life normally
(rather that just being more careful like most of us are when we have
one(s) who can't be vaccinated) and the ferrets became infected.  The
kits who had never had vaccines all died.  The older ferrets had been
vaccinated something like 3 (?) years before and I think 3 (?) of those
survived but the survivors had permanent damage.  It should be in the
archives somewhere.
 
Melatonin helps control symptoms of adrenal neoplasia and it may reduce
the onset of hormonally related malignancies but I know of no other use
for it.  Your bit of a description that I recall is not consistent with
adrenal neoplasia unless there are other things that you wrote which I
completely missed (entirely possible) and even then what I recall of
what you said would point to other things and the meds mentioned are not
consistent with adrenal problems either.  Actually, I can't offhand think
of anything that medication combo is consistent with (for whatever that
is worth or not worth).  Could you describe what is going on?  Diagnosis
or tentative diagnosis and how it was arrived at?  Yesterday you made a
mention of there being a malignancy but I do not recall you going into
what or the symptoms.  Guess I missed something you wrote.  BTW, although
they should come out except when not possible most adrenal growths are
not malignant so are not cancer and even a number of the adenocarcinomas
that come out do not spread.  It strikes me that there may be some
confusion which could be dispelled by an old FHL post originally from
2001 which has last been run here in November of 2002.  It is a Dr. Bruce
Williams one on what is and what is not "cancer".  Look for it at the
bottom of the FML today if Bill puts the FHL stuff in their normal
location (so that those who copy them can pick up any easily in one
sweep).
[Posted in FML issue 4118]