I have had excellent results with melatonin implants. Only twice has it not been really effective, though it has been effective numerous times. As for the Lupron, price around. Some vets give the injections for less, especially if you have to bring them in regularly. Also, Lupron can actually last for longer than a month. My vet said it's possible for the results to last two to three months. You can also put the ferret(s) on melatonin supplements and light therapy (12 hours of near darkness/12 hours of light), though this has to be done at exactly the same time every day in order for it to work properly. Debbie [Posted in FML 6597]